Ebola-based campaign
 

Or having survived. Hmmm. You could have a unit formed of early survivors, mostly military, for relief duties, and then have things fall further apart, leaving the group on their own.

Say, a doctor or nurse with extra training (for medical centric tasks), an engineer (for infrastructure tasks), and N grunts for muscle & boots ('just hold this, and hand it to me when I ask; you two lift on my command') and security.

... And two weeks in, the team gets a radio message from CDC regional HQ "There is a mob outside trying to break in here, I guess for food or medicine, and I have only six troops left not in a ward. Damn, I can hear them breaking in. You're going to have to go to the next regional HQ and try to contact them. I'd say try Cleveland, but they've been offline for three days.

"Good Luck, your on your own." (how else would it start? :) )

On the plus side, infrastructure would at least exist, although it would probably run down or be turned off to avoid untended damage.

As a game, you would have an immediate chaotic period, but no definitive opposition. You'd have to jump ahead a bit to get an organized opposition bigger than a gang, IMHO.

Uncle Ted

And all the stuff for WWIII works for this scenario as well! Rebuild, survive, scout and salvage. Mobs and chaos damage enough that it's a challenge. If your using V2/2.2, you can adapt T2013's careers or use Dark Conspiracy and it's Booster Kit for civvies, drop EMP, and skip Cyborg, ET, Android careers.