Cognito Ergo Doleo - 'I think, therefore I suffer' (or am depressed, depending on your translation). Kind of a reversal of 'Ignorance is bliss'.
I have been on the edge of my sanity at times, medically not just an expression, but have never quite got to the worst cases and feel for those examples given here.
My point, although already made, is that for me RPGs and all that are associated with them (such as this forum) have been my biggest saviour. Escapism, yes - and because of this I believe it has kept me from the worst. To be able to have like-minded friends and get away from the demons of modern life on a regular basis.
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