We're barely in the same situation where General is. We've not played a single module of Twilight:2000 in any of its versions, thought all of our games use the v2.2 timeline as a background. Hmmmm...a correction: We've used the "The Free City of Krakow" module but ignoring the "Operation Reset" plot. I think that Twilight:2000 admit a good number of approaches and different points of view. This forum is a good proof of it. For the future I'm planning to use some of the modules once my pre-Kalisz campaign will be over. Actually, one of the reason behind this campaign is to put the group (geographically and chronologically) where the old modules begin.
Beyond this, we've assaulted the Russian parliament as the KGB Alpha Team (a single adventure) and played a long campaign as soviet soldiers fighting to halt the NATO offensive in northern Poland. In the long term, I would like to referee a campaign with the players being Spanish civilians when things in Europe begin to fall apart. A kind of "Jericho" campaign with a nearby city blown up by a nuke, without centralized government, without food supplies or police protection and without all these things that we think we have granted for the rest of our lives.
So, my intention is not to advance far beyond the 2000 in the Twilight timeline, but to explore the same world from a different perspective. This remember me some adventure/campaign plots from a previous thread:
http://forum.juhlin.com/showthread.php?t=580