OOOOO! I love Ghost in the Shell and Appleseed! Such awesome big guns and who can resist power armour!? 
I rather doubt integral suppressors, etc will do much for the accuracy of the weapon. Barrel length and matching the number of twists to the ammo it's to fire is about the only real way you'll have any real effect.
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If it moves, shoot it, if not push it, if it still doesn't move, use explosives.
Nothing happens in isolation - it's called "the butterfly effect"
Mors ante pudorem
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