I doubt it. Doesn't take much to search online and find all sorts of photos and video of well endowed women firing rifles, machineguns and other things that go bang. Granted, most of it is more focused on semi-naked women who've never held a weapon before in their lives, but large breasts still don't seem to be a problem.
Depends also on what they're wearing. We've all heard of such things as sports bras which tend to flatten the chest. Any active woman is likely to be seeking this sort of apparel out in preference to anything more soft and lacy one would expect (dammit!).
As for a bullpup mag getting in the way, not a problem at all. Although located towards the rear of the weapon, it's still several inches from the buttplate.
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If it moves, shoot it, if not push it, if it still doesn't move, use explosives.
Nothing happens in isolation - it's called "the butterfly effect"
Mors ante pudorem
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