I'd imagine weed would be fairly easy to find.
Meth will probably be almost as easy to get as weed, at least for a while. Once the chemicals for making more run out...? With a breakdown of law and order, I'd think meth labs would be popping up all over. And exploding all over, too, at least until Amateur Hour has come and gone.
Crack and coke I think you can pretty much forget. Opiates too, unless someone starts growing the right kind of poppies domestically after the collapse.
IDK about LSD, though.
There are plenty of natural substitutes for some of these substances (esp. LSD; I can think of at least two plants that can give a similar effect without having to search teh interwebz), so while the use of the particular drug might drop off, between the sorry state of the world and the need/desire to turn alcohol into fuel rather than booze, as well as the fact that it seems like it's always the scumbags and gangers (redundant, I know) that survive, I'd expect drug use overall will probably increase. At least as far as 'drug users as a percentage of the population' goes.
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