@Kato,
You could - but the rules are for platoon / company level action with individual fire teams, leaders and support weapons being the "units of manoeuvre" for want of a better term. I think with much above a company the game would bog down unless you had multiple players. I think most people play with 15-20mm figures - it would certainly work with 10mm. Board size is typically from 2 feet by 2 feet up to 4 feet by 4 feet - a lot of the modern scenarios are set in built up areas so you need lots of terrain.
I really like the rules.
An alternative set of skirmish rules specifically designed for Afghanistan is
Skirmish Sangin which can be found here:
http://www.radiodishdash.co.uk/
Malc