This idea does have some merit. In Scott Sigler's book, Contagious, a similar measure was used to contain a potential pandemic outbreak.
The only obstacle in the way seems to be a doctrine change in the Project. Somewhere between 3rd edition and 4th edition there must have been some discussion about the fusion demolition charge. That item is not present in 4th edition. That being said, it could be argued that the fusion demolition charge was pulled from the field and no longer included in the MARS-One loadout but a few may have been kept in reserve at Prime Base and the alternate base under the control of the highest levels of the Project.
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