Grey Area
Technically, I probably didn't use the term MacGuffin correctly in the OP/Poll, but there's definitely a difference between "an object or device in a movie or a book that serves merely as a trigger for the plot" and a mission like "gather stuff", or a patron that sends the character on missions, like "the collector". A MacGuffin is almost always one really important thing. How and/or why it's important usually doesn't matter to the character charged with finding/retrieving/destroying the thing, but it still manages to drive the main plot line.
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