Amputations
It hasn't been all that long, historically speaking, that surgeons have been able to reconstruct badly damaged limbs. Prior to the medical breakthroughs- imaging, grafting, hardware, tissue transplants, etc.) that allowed for that, amputation was often the only viable option.
As hospitals run out of the tech and tools to repair shattered bone and/or badly mangled tissue, amputation would reassume its place as the go-to treatment for "limbs beyond saving" (or rather, more wounded limbs would classify, by default, as "limbs beyond saving"). Also, a loss of human capital (i.e. highly trained, experienced orthopedic surgeons) would mean that a large proportion of those medical professionals that remain c.2000 would be lacking in the skill department. "Sawbones" would once again become an appropriate appellation for many ersatz doctors in the late Twilight War.
By 2000, there would be a higher than average number- per capita especially- of amputees in the world. It's a likely phenomenon worth noting when constructing NPCs or describing settlements.
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