The M134 was trialled in the Vietnam war mounted on an M113. Although extremely effective, it was quickly decided not to use it in this manner due to the extreme wastage of ammunition.
It was like firing 10 M60's all at the one target point - nothing left, but it only takes one bullet to do the job, not hundreds....
I'd say let your players mount it but don't tell them just how much ammo they're about to chew through with little real result. You might also want to pay attention to the feed system - if they don't have one, then they're likely to run into problems with snagged belts, stretched links (when the belts snag), the need to reload every second action, etc, etc, etc
Mounted on a tripod in a stationary role should eliminate most of the feed issues (provided they've had time to lay out a few thousand rounds and don't need to swing the weapon around too much), but they'll still be firing way more ammo than they need to to get the job done.
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If it moves, shoot it, if not push it, if it still doesn't move, use explosives.
Nothing happens in isolation - it's called "the butterfly effect"
Mors ante pudorem
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