Construction and fuel mix will cause a lot of variation. Off hand I would say take the explosive weight, assume C4 and multiply the DPW by 3 to get the resultant blast plus a fireball of 1200C that covers the blast radius for 1-2 sec would be a good place to start if you needed something fast. I don't think the shockwave + vacuum effect really needs to be exploited. The larger DPW per unit mass is just simpler and gets the job done.
I may have to look more thoroughly into this later.
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