As always the "best mix" is going to depend on your mix of players. My table always consisted of mostly fellow-vets, so they tended to be more "mission focused" and less impressed by the armament (and therefore less-inclined to abuse such armament).
Given that general attitude, the situations that worked best were the ones where I had specific idea of The Problem and The Opposition, and only a vague conception of One Possible Solution. In these cases I knew what to describe and how to describe it, knew what the goals and resources of the opposing group (if there was one) were, and then just turned the Team loose in the sandbox. My One Possible Solution rarely, if ever, came into play because they came up with other ways to deal with the issue.
Just keep things internally consistent and be prepared to improvise, and you're good to go.
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