I have long considered running T2K under the GURPS rules. When I do so, it will probably be under the 4e rules, since I have a copy of GURPS Update so I can readily convert my 3e stuff to 4e as necessary. Also, I really like 4e...it allows me to tweak things more than 3e did.
My biggest problem is the lack of vehicles pre-statted for 4e. But that is not really that overwhelming of an obstacle, since there are literally hundreds of vehicles statted out for 3e (many of them in the old "Vehicle of the Week" archive) and I will eventually crunch out 4e stats for the vehicles that I want to use.
The other "problem" with running T2K under GURPS is lethality. It is VERY easy for a character in GURPS to get killed, particularly in gun combat. But if the PCs are careful (and my usual bunch of players are), they will do fine.
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