V2.2 doubled the NPC points from 20 to 40 making NPCs tougher than some PCs.
And don't forget the instant kill rule - any aimed shot which hits the heat or chest has a chance of inflicting at least a serious wound (even if the weapon is just somethign as pathetic as a .22). PCs watch out for snipers and NPCs with a spare aim action on their hands... 
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If it moves, shoot it, if not push it, if it still doesn't move, use explosives.
Nothing happens in isolation - it's called "the butterfly effect"
Mors ante pudorem
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