v2.2 Special Injury Effects

[TyCaine]

As noted this is for the v2.2 system, but I was wondering if anyone had any house rules around certain special injuries and their effects on play?

For instance, if someone loses a finger, or hand, forearm or even whole arm, assuming they survive, how would that effect their stats and game play from then on?
Losing a foot, lower leg or whole leg.
Losing an eye, or whatever.

I have a player who has a disability, and he wants to emulate that in the game world so I was wondering whether anyone had already come up with stat modifiers for such things?

Thanks in advance!

~Ty